α-Thioalkylation of Zinc Dienolates as an Entry to 4-Substituted 1-tert-Butoxy-7a-methylhexahydroindenes

Authors

  • Thomas Köhler Fachbereich Chemie und Konstanz Research School Chemical Biology der Universität Konstanz, Universitätsstrasse 10, Fach 720, D-78457 Konstanz, Germany.
  • Thomas Huhn Fachbereich Chemie und Konstanz Research School Chemical Biology der Universität Konstanz, Universitätsstrasse 10, Fach 720, D-78457 Konstanz, Germany.
  • Ulrich Groth Fachbereich Chemie und Konstanz Research School Chemical Biology der Universität Konstanz, Universitätsstrasse 10, Fach 720, D-78457 Konstanz, Germany.

DOI:

https://doi.org/10.17721/fujcV3I1P29-45

Keywords:

Zinc dienolates, Thioalkylation of Indene derivatives, Steroids

Abstract


Hexahydroindenes 10 are readily available in 3 steps with an overall yield of 41 – 45 % starting from the Hajos Wiechert ketone 1. Alkylation of the α,β-unsaturated ketone 1 at C-4 has been achieved by thioalkylation of the corresponding zinc dienolate 2 with α-chlorosulfides of type 3. Subsequent in situ reduction and desulfurization of the β-(phenylthio) ketones 4 leads directly to the 4-substituted hexahydroindene-5-ols 6 which can be deoxygenated via their mesylates to the hexahydroindenes 10.

References

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2015-03-10

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