Efficient Synthesis Of 5-Substituted Ethyl 1,2,4-Triazole-3-Carboxylates


  • Dmytro M. Khomenko Department of Chemistry, Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64, Kyiv, Ukraine
  • Roman O. Doroschuk Department of Chemistry, Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64, Kyiv, Ukraine
  • Rostyslav D. Lampeka Department of Chemistry, Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64, Kyiv, 01033, Ukraine




1, 2, 4-triazole, carbethoxyformimidate, acylamidrazone, cyclocondensation, acylhydrazide


Easily accessible carboxylic acid hydrazides undergo cyclocondensation with ethyl carbethoxyformimidate, giving 5-substituted ethyl 1,2,4-triazole-3-carboxylates. These are important building blocks in organic synthesis. The approach we used to obtain title compounds made possible synthesis of 3-(2-aminophenyl)-1,2,4-triazole


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