Efficient Synthesis Of 5-Substituted Ethyl 1,2,4-Triazole-3-Carboxylates

Dmytro M. Khomenko, Roman O. Doroschuk, Rostyslav D. Lampeka


Easily accessible carboxylic acid hydrazides undergo cyclocondensation with ethyl carbethoxyformimidate, giving 5-substituted ethyl 1,2,4-triazole-3-carboxylates. These are important building blocks in organic synthesis. The approach we used to obtain title compounds made possible synthesis of 3-(2-aminophenyl)-1,2,4-triazole


1,2,4-triazole; carbethoxyformimidate; acylamidrazone; cyclocondensation; acylhydrazide

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DOI: https://doi.org/10.17721/fujcV4I2P28-32


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