Quantitative Determination of Lincomycin in Dosage Forms by Iodometric Titration through Oxidation Reaction with Peroxomonosulfate

Authors

  • Mykola Blazheyevskiy Department of General Chemistry of National University of Pharmacy, Pushkinska street, 53, Kharkiv, Ukraine
  • Olena Mozgova Department of General Chemistry of National University of Pharmacy, Pushkinska street, 53, Kharkiv, Ukraine http://orcid.org/0000-0003-0875-7035
  • Valeriy Moroz Department of Analytical Chemistry and Analytical Toxicology of National University of Pharmacy, Pushkinska street, 53, Kharkiv, Ukraine

DOI:

https://doi.org/10.17721/fujcV11I1P17-29

Keywords:

Lincomycin, iodometry, oxidimetric titration, oxone

Abstract

The kinetics of the oxidation reaction of Lincomycin hydrochloride (Link) with potassium hydrogen peroxomonosulfate (KHSO5) was studied depending on the pH of the medium. It has been established that the reaction kinetics obeys the general laws of specific acid-base catalysis. KHSO5 reacts quantitatively with Link in an alkaline medium to form the corresponding sulfone-N-oxide: 1 mole of Link requires 3 moles of KHSO5. Methods for the oxidimetric determination of Link were developed using KHSO5 as an analytical reagent: a known excess of the reagent is added and after a specified time, its residual amount is determined by iodometry. The possibility of quantitative determination of the main substance in the substance of Link hydrochloride, as well as the determination of Link hydrochloride solution for injection "Lincomycin-Zdorovye" 300 mg/ml in ampoules of 1 ml and capsules of 0.25 g were shown. RSD does not exceed 1.7%.

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Published

2023-07-22

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