Assessment of the State of Platelet Haemostasis and Adhesive - Aggregation Properties of Platelets as a Factor of Increasing the Tendency to Thrombosis in Chronic Inflammation


  • Irina Sokolovskaya Zaporizhzhya State Medical University and Khorticky National Academy
  • Nataliia Prybora National Pedagogical Dragomanov University
  • Valentyna Nechyporenko Khortytsia National Academy
  • Olena Pozdniakova Khortytsia National Academy
  • Nataliia Hordiienko Khortytsia National Academy
  • Kostiantyn Nechyporenko Khortytsia National Academy
  • Yuliia Siliavina Khortytsia National Academy
  • Vitalii Mavrin Khortytsia National Academy
  • Andriy Kotuza Clinical Hospital "Feofania" the State Management of Affairs
  • Oleksandr Kliusov City Oncology Center
  • Iryna Kryachok National institute of cancer
  • Iryna Tytorenko National institute of cancer
  • Valery Zub Dispensario oncologico regionale di Chernigiv
  • Lesya Yanitka Bogomolets National Medical University
  • Nina Hordienko Pedagogical University of Drogobych
  • Marharyta Kudinova Khortytsia National Academy
  • Zhalie Mamedli University of Cologne, Germany
  • Lyudmila Hordiienko Clinical Hospital "Feofania" the State Management of Affairs
  • Yaroslav Kmetyuk Clinical Hospital "Feofania" the State Management of Affairs
  • Nataliia Sprynchuk Institute of Endocrinology



von Willebrand factor, adhesion, aggregation, platelets, thrombosis


In recent decades, considerable progress has been made in understanding the functional mechanisms of platelets and the correction of platelet haemostasis. Platelets are considered the most important participants in both the normal and pathological thrombotic processes characteristic of a variety of diseases and conditions. Alterations in various limbs of haemostasis are found in many somatic diseases (atherosclerosis, coronary heart disease, stroke), surgical procedures, oncological and immunological diseases. Inflammation underlies most diseases and remains an urgent problem in medicine. In the leukocyte infiltration of the inflammatory focus, the mechanism of its self-preservation is of great importance. The activation of haematopoiesis during inflammation is triggered by factors released by stimulated leukocytes of the focus and peripheral blood. Therefore, the problem of the state of the haemostasis system should be the focus of constant attention of clinicians, and with the help of laboratory monitoring of the state of the haemostasis system, it is possible to carry out drug correction of the haemocoagulation potential.

Author Biography

Irina Sokolovskaya, Zaporizhzhya State Medical University and Khorticky National Academy

Chair of Biochemistry and chair of Hygiene


De Maat S, Maas C. Factor XII: form determines function. Journal of Thrombosis and Haemostasis 2016;14(8):1498-1506.

McNicol A, Israels S. Beyond Hemostasis: The Role of Platelets in Inflammation, Malignancy and Infection. Cardiovascular & Hematological Disorders-Drug Targets 2008;8(2):99-117.

Li Z, Yang F, Dunn S, Gross A, Smyth S. Platelets as immune mediators: Their role in host defense responses and sepsis. Thrombosis Research 2011;127(3):184-188.

Stark R, Aghakasiri N, Rumbaut R. Platelet-Derived Toll-Like Receptor 4 (Tlr-4) Is Sufficient to Promote Microvascular Thrombosis in Endotoxemia. PLoS ONE 2012;7(7):e41254.

Kerrigan S, Cox D. Platelet–bacterial interactions. Cellular and Molecular Life Sciences 2009;67(4):513-523.

Gleissner C, von Hundelshausen P, Ley K. Platelet Chemokines in Vascular Disease. Arteriosclerosis, Thrombosis, and Vascular Biology 2008;28(11):1920-1927.

Weyrich A, Zimmerman G. Platelets: signaling cells in the immune continuum. Trends in Immunology 2004;25(9):489-495.

Sokolovskaya I, Nechiporenko V, Gordiyenko N, Pozdnyakova O, Volkova S, Cymbal V, Makurina G. Lipid peroxidation during chronic inflammation. French-Ukrainian Journal of Chemistry 2018;6(2):38-53.

Menshikov VV. Clinical laboratory analytics. Volume III. Private search technologies in the lab lab. M: Labpress; 2000. – 384с.

Nazarenko GI, Kishkun AA. Clinical evaluation of laboratory studies. Kyiv: Medicine; 2000.

Baluda VP, Barkagan ES, Goldberg ED. Laboratory methods for studying hemostasis. Tomsk, 1980. 310 p.

Handbook / ed. professor Karpishchenko AI. Medical laboratory diagnostics (programs and algorithms). Kyiv: Intermedica; 2001 - 544 p.

Makurina H, Мakarchuk O, Dmytrenko I, Holovkin A, Sokolovska I, Chornenka A. Verrucous leukoplakia of the red border caused by the use of IQOS heated tobacco product (a case report). Zaporozhye Medical Journal 2020;22(6):885-890.

Sokolovskaya I. Features of Indicators of Blood General Clinical Analysis and the Summary Analysis of an Organism’s General Reactivity at Chronic Inflammatory Process. French-Ukrainian Journal of Chemistry 2022;10(1):84-100.

Weyrich A, Lindemann S, Tolley N, Kraiss L, Dixon D, Mahoney T, Prescott S, McIntyre T, Zimmerman G. Change in Protein Phenotype without a Nucleus: Translational Control in Platelets. Seminars in Thrombosis and Hemostasis 2004;30(4):491-498.