Assessment of the State of Platelet Haemostasis and Adhesive - Aggregation Properties of Platelets as a Factor of Increasing the Tendency to Thrombosis in Chronic Inflammation

Authors

  • Irina Sokolovskaya Zaporizhzhya State Medical University and Khorticky National Academy http://orcid.org/0000-0002-5664-2382
  • Nataliia Prybora National Pedagogical Dragomanov University
  • Valentyna Nechyporenko Khortytsia National Academy
  • Olena Pozdniakova Khortytsia National Academy
  • Nataliia Hordiienko Khortytsia National Academy
  • Kostiantyn Nechyporenko Khortytsia National Academy
  • Yuliia Siliavina Khortytsia National Academy
  • Vitalii Mavrin Khortytsia National Academy
  • Andriy Kotuza Clinical Hospital "Feofania" the State Management of Affairs
  • Oleksandr Kliusov City Oncology Center
  • Iryna Kryachok National institute of cancer
  • Iryna Tytorenko National institute of cancer
  • Valery Zub Dispensario oncologico regionale di Chernigiv
  • Lesya Yanitka Bogomolets National Medical University
  • Nina Hordienko Pedagogical University of Drogobych
  • Marharyta Kudinova Khortytsia National Academy
  • Zhalie Mamedli University of Cologne, Germany
  • Lyudmila Hordiienko Clinical Hospital "Feofania" the State Management of Affairs
  • Yaroslav Kmetyuk Clinical Hospital "Feofania" the State Management of Affairs
  • Nataliia Sprynchuk Institute of Endocrinology

DOI:

https://doi.org/10.17721/fujcV10I2P22-36

Keywords:

von Willebrand factor, adhesion, aggregation, platelets, thrombosis

Abstract

In recent decades, considerable progress has been made in understanding the functional mechanisms of platelets and the correction of platelet haemostasis. Platelets are considered the most important participants in both the normal and pathological thrombotic processes characteristic of a variety of diseases and conditions. Alterations in various limbs of haemostasis are found in many somatic diseases (atherosclerosis, coronary heart disease, stroke), surgical procedures, oncological and immunological diseases. Inflammation underlies most diseases and remains an urgent problem in medicine. In the leukocyte infiltration of the inflammatory focus, the mechanism of its self-preservation is of great importance. The activation of haematopoiesis during inflammation is triggered by factors released by stimulated leukocytes of the focus and peripheral blood. Therefore, the problem of the state of the haemostasis system should be the focus of constant attention of clinicians, and with the help of laboratory monitoring of the state of the haemostasis system, it is possible to carry out drug correction of the haemocoagulation potential.

Author Biography

Irina Sokolovskaya, Zaporizhzhya State Medical University and Khorticky National Academy

Chair of Biochemistry and chair of Hygiene

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Published

2022-12-29

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