Assessment of the State of Platelet Haemostasis and Adhesive - Aggregation Properties of Platelets as a Factor of Increasing the Tendency to Thrombosis in Chronic Inflammation

Authors

  • Irina Sokolovskaya Zaporizhzhya State Medical University and Khorticky National Academy http://orcid.org/0000-0002-5664-2382
  • Nataliia Prybora National Pedagogical Dragomanov University
  • Valentyna Nechyporenko Khortytsia National Academy
  • Olena Pozdniakova Khortytsia National Academy
  • Nataliia Hordiienko Khortytsia National Academy
  • Kostiantyn Nechyporenko Khortytsia National Academy
  • Yuliia Siliavina Khortytsia National Academy
  • Vitalii Mavrin Khortytsia National Academy
  • Andriy Kotuza Clinical Hospital "Feofania" the State Management of Affairs
  • Oleksandr Kliusov City Oncology Center
  • Iryna Kryachok National institute of cancer
  • Iryna Tytorenko National institute of cancer
  • Valery Zub Dispensario oncologico regionale di Chernigiv
  • Lesya Yanitka Bogomolets National Medical University
  • Nina Hordienko Pedagogical University of Drogobych
  • Marharyta Kudinova Khortytsia National Academy
  • Zhalie Mamedli University of Cologne, Germany
  • Lyudmila Hordiienko Clinical Hospital "Feofania" the State Management of Affairs
  • Yaroslav Kmetyuk Clinical Hospital "Feofania" the State Management of Affairs
  • Nataliia Sprynchuk Institute of Endocrinology

DOI:

https://doi.org/10.17721/fujcV10I2P22-36

Keywords:

von Willebrand factor, adhesion, aggregation, platelets, thrombosis

Abstract

In recent decades, considerable progress has been made in understanding the functional mechanisms of platelets and the correction of platelet haemostasis. Platelets are considered the most important participants in both the normal and pathological thrombotic processes characteristic of a variety of diseases and conditions. Alterations in various limbs of haemostasis are found in many somatic diseases (atherosclerosis, coronary heart disease, stroke), surgical procedures, oncological and immunological diseases. Inflammation underlies most diseases and remains an urgent problem in medicine. In the leukocyte infiltration of the inflammatory focus, the mechanism of its self-preservation is of great importance. The activation of haematopoiesis during inflammation is triggered by factors released by stimulated leukocytes of the focus and peripheral blood. Therefore, the problem of the state of the haemostasis system should be the focus of constant attention of clinicians, and with the help of laboratory monitoring of the state of the haemostasis system, it is possible to carry out drug correction of the haemocoagulation potential.

Author Biography

Irina Sokolovskaya, Zaporizhzhya State Medical University and Khorticky National Academy

Chair of Biochemistry and chair of Hygiene

References

De Maat S, Maas C. Factor XII: form determines function. Journal of Thrombosis and Haemostasis 2016;14(8):1498-1506. https://doi.org/10.1111/jth.13383

McNicol A, Israels S. Beyond Hemostasis: The Role of Platelets in Inflammation, Malignancy and Infection. Cardiovascular & Hematological Disorders-Drug Targets 2008;8(2):99-117. https://doi.org/10.2174/187152908784533739

Li Z, Yang F, Dunn S, Gross A, Smyth S. Platelets as immune mediators: Their role in host defense responses and sepsis. Thrombosis Research 2011;127(3):184-188. https://doi.org/10.1016/j.thromres.2010.10.010

Stark R, Aghakasiri N, Rumbaut R. Platelet-Derived Toll-Like Receptor 4 (Tlr-4) Is Sufficient to Promote Microvascular Thrombosis in Endotoxemia. PLoS ONE 2012;7(7):e41254. https://doi.org/10.1371/journal.pone.0041254

Kerrigan S, Cox D. Platelet–bacterial interactions. Cellular and Molecular Life Sciences 2009;67(4):513-523. https://doi.org/10.1007/s00018-009-0207-z

Gleissner C, von Hundelshausen P, Ley K. Platelet Chemokines in Vascular Disease. Arteriosclerosis, Thrombosis, and Vascular Biology 2008;28(11):1920-1927. https://doi.org/10.1161/atvbaha.108.169417

Weyrich A, Zimmerman G. Platelets: signaling cells in the immune continuum. Trends in Immunology 2004;25(9):489-495. https://doi.org/10.1016/j.it.2004.07.003

Sokolovskaya I, Nechiporenko V, Gordiyenko N, Pozdnyakova O, Volkova S, Cymbal V, Makurina G. Lipid peroxidation during chronic inflammation. French-Ukrainian Journal of Chemistry 2018;6(2):38-53. https://doi.org/10.17721/fujcv6i2p38-53

Menshikov VV. Clinical laboratory analytics. Volume III. Private search technologies in the lab lab. M: Labpress; 2000. – 384с.

Nazarenko GI, Kishkun AA. Clinical evaluation of laboratory studies. Kyiv: Medicine; 2000.

Baluda VP, Barkagan ES, Goldberg ED. Laboratory methods for studying hemostasis. Tomsk, 1980. 310 p.

Handbook / ed. professor Karpishchenko AI. Medical laboratory diagnostics (programs and algorithms). Kyiv: Intermedica; 2001 - 544 p.

Makurina H, Мakarchuk O, Dmytrenko I, Holovkin A, Sokolovska I, Chornenka A. Verrucous leukoplakia of the red border caused by the use of IQOS heated tobacco product (a case report). Zaporozhye Medical Journal 2020;22(6):885-890. https://doi.org/10.14739/2310-1210.2020.6.218477

Sokolovskaya I. Features of Indicators of Blood General Clinical Analysis and the Summary Analysis of an Organism’s General Reactivity at Chronic Inflammatory Process. French-Ukrainian Journal of Chemistry 2022;10(1):84-100. https://doi.org/10.17721/fujcv10i1p84-100

Weyrich A, Lindemann S, Tolley N, Kraiss L, Dixon D, Mahoney T, Prescott S, McIntyre T, Zimmerman G. Change in Protein Phenotype without a Nucleus: Translational Control in Platelets. Seminars in Thrombosis and Hemostasis 2004;30(4):491-498. https://doi.org/10.1055/s-2004-833484

Downloads

Published

2022-12-29

Issue

Vol. 10 No. 2 (2022)

Section

Articles

License

Copyright (c) 2022 French-Ukrainian Journal of Chemistry

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).