Development and Validation of a Simple Procedure for the Kinetic Spectrophotometric Quantitative Determination of Ceftriaxone Using Potassium Caroate

Mykola Blazheyevskiy; Yuliia Serdiukova; Svitlana Karpova

doi:10.17721/fujcV10I1P1-12

Authors

Mykola Blazheyevskiy National University of Pharmacy, 53, Pushkinska str., Kharkiv, 61002, Ukraine
Yuliia Serdiukova National University of Pharmacy, 53, Pushkinska str., Kharkiv, 61002, Ukraine
Svitlana Karpova National University of Pharmacy, 53, Pushkinska str., Kharkiv, 61002, Ukraine

DOI:

https://doi.org/10.17721/fujcV10I1P1-12

Keywords:

Ceftriaxone, Potassium Caroate, spectrophotometry, kinetics

Abstract

A simple procedure for the quantitative determination of the Ceftriaxone pure substance by the spectrophotometric method in its kinetic modification using Caro’s acid has been developed and validated. The scheme of the chemical transformation of Ceftriaxone with the reaction of potassium caroate has been proposed. The appearance of a new wave gives the possibility of developing a new procedure for the quantitative determination of Ceftriaxone. The obtained results of accuracy and precision are as follows: RSD = 1.63-2.25 %, δ = 0.33-0.96 %. LOD = 0.1 µg/mL, LOQ = 0.33 µg/mL.

References

European Pharmacopoeia. 4 ed. (2003). Strasbourg: Council of Europe: 2975-7.

European Pharmacopoeia. 6 ed. Vol. 1. (2007) Strasbourg: EDQM: 1084.

British pharmacopoeia. Vol. 1. (2007) London: The stationary office: 666-7.

The United States pharmacopeia. National formulary. Vol. 1. Rockville (MD) The united state pharmacopeial convention INC twin brook parkway; 2003: 498-9.

Derzhavna Farmakopeya Ukrayiny. Vol. 1. (2001). Kharkiv: Derzhavne pidpryyemstvo «Naukovo-ekspertnyi farmakopeinyi tsentr», 477.

Derzhavna Farmakopeya Ukrayiny. Vol. 1. (2008). Kharkiv: Derzhavne pidpryyemstvo «Naukovo-ekspertnyi farmakopeinyi tsentr», 620.

Farmatsevtycheskaia khymyia: ucheb. Posobye (2004). Moscow: HEOTAR-MED, 640.

Gallo Martı́nez L, Campı́ns Falcó P, Sevillano Cabeza A. Comparison of several methods used for the determination of cephalosporins. Analysis of cephalexin in pharmaceutical samples. Journal of Pharmaceutical and Biomedical Analysis 2002;29(3):405-423. https://doi.org/10.1016/s0731-7085(02)00089-4

Nabi SA, Abu-Nameh ESM, Helalch MIH. Titrimetric method followed by spectrophotometric determination of some selected cephalosporins. Chem anal. 1997;42(6):881-886.

Blazheyesvky MYe, Labuzova YuYu. Yodometrychne vyznachennia tsefaleksynu ta tsefotaksymu za reaktsiieiu z kalii karoatom. News of Pharmacy. 2011;68(4):49-52.

Blazheyesvky MYe, Labuzova YuYu. Yodometrychne vyznachennia tsefazolinu za reaktsiieiu z kaliiu hidrohenkaroatom. News of Pharmacy. 2012;71(3):48-51.

Blazheyesvky MYe, Labuzova YuYu. Validatsiia yodometrychnoi metodyky kilkisnoho vyznachennia tsefaleksynu u substantsii. Problemy ekolohichnoi ta medychnoi henetyky i klinichnoi imunolohii. 2013;5(119):175-182.

Serdiukova YuYu, Leonova SG. Yodometrychne vyznachennia tsefadroksylu za reaktsiieiu z kalii hidrohenkaroatom. Science Rise. 2015;15(10/4):36-41. https://doi.org/10.15587/2313-8416.2015.52004

Serdiukova Y, Ivashura M, Oleksienko T. Iodometric determination of cefuroxime by the potassium hydrogenperoxomonosulphate reaction. Vìsnik farmacìï 2016;86(2):6-8. https://doi.org/10.24959/nphj.16.2068

Shrivastava SM, Singh R, Tariq A. A Novel High Performance Liquid Chromatographic Method for Simultaneous Determination of Ceftriaxone and Sulbactam in Sulbactomax. Int. J. Biomed. Sci. 2009;5(1):37–43.

Sun H, Wang H, Ge X. Simultaneous Determination of the Combined Drugs of Ceftriaxone Sodium, Metronidazole, and Levofloxacin in Human Urine by High-Performance Liquid Chromatography. Journal of Clinical Laboratory Analysis 2012;26(6):486-492. https://doi.org/10.1002/jcla.21551

Glaría M, Moscciati G, Ramos R. Determination of Ceftriaxone in Cerebrospinal Fluid by Ion-Pair Liquid Chromatography. Journal of AOAC Int. 2005;88(2):436-439. https://doi.org/10.1093/jaoac/88.2.436

Gallo Martı́nez L, Campı́ns Falcó P, Sevillano Cabeza A. Comparison of several methods used for the determination of cephalosporins. Analysis of cephalexin in pharmaceutical samples. Journal of Pharmaceutical and Biomedical Analysis 2002;29(3):405-423. https://doi.org/10.1016/s0731-7085(02)00089-4

Baranowska I, Markowski P, Baranowski J. Simultaneous determination of 11 drugs belonging to four different groups in human urine samples by reversed-phase high-performance liquid chromatography method. Analytica Chimica Acta 2006;570(1):46-58. https://doi.org/10.1016/j.aca.2006.04.002

Hiremath B, Mruthyunjayaswamy B. Development and Validation of a High-Performance Liquid Chromatographic Determination of Ceftriaxone Sodium and Its Application to Drug Quality Control. Analytical Letters 2009;42(14):2180-2191. https://doi.org/10.1080/00032710903139802

De Diego M, Godoy G, Mennickent S. Chemical Stability Of Ceftriaxone By A Validated Stability-Indicating Liquid Chromatographic Method. Journal of the Chilean Chemical Society 2010;55(3):335-337. https://doi.org/10.4067/s0717-97072010000300013

Campos M, de Moura Alonso J, dos Santos Martins E, Oliveira J, Hussni C, Peccinini R. Ceftriaxone pharmacokinetics by new simple and sensitive ultra-high-performance liquid chromatography method. Diagnostic Microbiology and Infectious Disease 2017;88(1):95-99. https://doi.org/10.1016/j.diagmicrobio.2017.02.012

Phattanawasin P, Sotanaphun U, Sriphong L, Kanchanaphibool I. Stability-indicating TLC-image analysis method for quantification of Ceftriaxone sodium in pharmaceutical dosage forms. Journal of Planar Chromatography – Modern TLC 2011;24(1):30-34. https://doi.org/10.1556/jpc.24.2011.1.5

Guru Prasad AR, Rao VS. Polarographic determination of certain cephalosporins in pharmaceutical preparations. Res. Pharm. Sci. 2010;5(1):57-63.

Ogorevc B, Hudnik V, Gomišček S. Polarographic analysis of some cephalosporin antibiotics. Fresenius' Zeitschrift für Analytische Chemie 1988;330(1):59-64. https://doi.org/10.1007/bf00494537

Ogorevc B, Gomišček S. Electrochemical analysis of cephalosporin antibiotics. Journal of Pharmaceutical and Biomedical Analysis 1991;9(3):225-236. https://doi.org/10.1016/0731-7085(91)80151-x

Majdi S, Jabbari A, Heli H, Yadegari H, Moosavi-Movahedi A, Haghgoo S. Electrochemical oxidation and determination of ceftriaxone on a glassy carbon and carbon-nanotube-modified glassy carbon electrodes. Journal of Solid State Electrochemistry 2008;13(3):407-416. https://doi.org/10.1007/s10008-008-0567-6

Altinoz S, Temizer A, Beksac S. Determination of ceftriaxone in biological material by differential-pulse adsorptive stripping voltammetry. The Analyst 1990;115(6):873. https://doi.org/10.1039/an9901500873

Aleksic M, Lijeskic N, Pantic J, Kapetanovic V. Electrochemical behavior and differential pulse voltammetric determination of ceftazidime, cefuroxime-axetil and ceftriaxone. Facta universitatis - series: Physics, Chemistry and Technology 2013;11(1):55-66. https://doi.org/10.2298/fupct1301055a

Patel S, Patel N, Patel M. Spectrophotometric methods for the estimation of Cephalexin in tablet dosage forms. Indian Journal of Pharmaceutical Sciences 2006;68(2):278. https://doi.org/10.4103/0250-474x.25740

Talebpour Z, Tavallaie R, Ahmadi S, Abdollahpour A. Simultaneous determination of penicillin G salts by infrared spectroscopy: Evaluation of combining orthogonal signal correction with radial basis function-partial least squares regression. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2010;76(5):452-457. https://doi.org/10.1016/j.saa.2010.01.002

Salem H, Askal H. Colourimetric and AAS determination of cephalosporins using Reineck's salt. Journal of Pharmaceutical and Biomedical Analysis 2002;29(1-2):347-354. https://doi.org/10.1016/s0731-7085(02)00040-7

Pérez-Bendito D, Gómez-Hens A, Silva M. Advances in drug analysis by kinetic methods. Journal of Pharmaceutical and Biomedical Analysis 1996;14(8-10):917-930. https://doi.org/10.1016/0731-7085(95)01673-2

Saleh G, El-Shaboury S, Mohamed F, Rageh A. Kinetic spectrophotometric determination of certain cephalosporins using oxidized quercetin reagent. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2009;73(5):946-954. https://doi.org/10.1016/j.saa.2009.05.002

Omar MA, Abdelmageeda OH, Attiaa TZ. Kinetic spectrofluorimetric determination of certain cephalosporins in human plasma. Talanta 2009;77(4):1394-1404. https://doi.org/10.1016/j.talanta.2008.09.040

Ilyas SA, Imran Md, Kumar N, Shah J, Jan MR, Kousar Z, Aslam M. Development of Spectrophotometric Method for Determination of Ceftriaxone Sodium in Different Brands of Pharmaceutical Preparation Involving Diazotization. International Journal of Pharmaceutical Sciences And Research 2015;6(12):5164-73.

Majani AV, Paradkar MU. Development and Validation of UV Spectrophotometric Method for the Estimation of Ceftriaxone Sodium in Nanoparticles. Der Pharma Chemica. 2018;10(3):151-157.

Patel S, Patel N, Patel M. Spectrophotometric estimation of cefotaxime and ceftriaxone in pharmaceutical dosage forms. Indian Journal of Pharmaceutical Sciences 2006;68(1):101. https://doi.org/10.4103/0250-474x.22977

Hassan EM, Mahrous MS, Shdeed RN. Stability-Indicating Spectrophotometric Methods for The Determination of Ofloxacin and Ceftriaxone and Their Degradation Products. J. Pharm. Biomed.Sci. 2012;18(03):99-110.

Blazheyesvky MYe, Labuzova YuYu. Kinetychne spektrofotometrychne vyznachennia tsefazolinu za produktom reaktsii peroksykyslotnoho okysnennia ta perhidrolizu. Pharm. J. 2012;4:76-80.

Blazheyevskiy MYe, Labuzova YuYu.. Kinetic spectrophotometric determination of cefadroxil in pure substance and pharmaceutical dosage form. J. Chem. Pharm. Res. 2013;5(8):115-121.

Blazheyesvky MYe, Labuzova YuYu. Kinetychne spektrofotometrychne vyznachennia tsefaleksynu za produktom reaktsii peroksokyslotnoho okysnennia ta perhidrolizu. News Pharm. 2010;6(22):30-33.