Relationship of the content of vitamin D and melatonin in blood serum and pineal gland calcifications in patients with malignant bone tumors
DOI:
https://doi.org/10.17721/fujcV9I1P63-69Keywords:
pineal calcifications, melatonin, vitamin DAbstract
The aim of the study was to investigate the relationship between the vitamin D content, melatonin and the characteristics of pineal gland calcifications in patients with malignant tumors of the bones of the lower extremities. Vitamin D deficiency and pineal gland calcifications are observed in almost 100 % of patients with malignant tumors of the lower extremities’ bones. The high heterogeneity of calcifications and its dynamics during the treatment of patients may indicate the processes of their litholysis and dissolution.
References
Boutin J, Jockers R. Melatonin controversies, an update. Journal of Pineal Research 2020;70(2)::e12702. https://doi.org/10.1111/jpi.12702
Cipolla-Neto J, Amaral F. Melatonin as a Hormone: New Physiological and Clinical Insights. Endocrine Reviews 2018;39(6):990-1028. https://doi.org/10.1210/er.2018-00084
Toma C, Svoboda M, Arrich F, Ekmekcioglu C, Assadian O, Thalhammer T. Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors. Journal of Pineal Research 2007;43(2):206-213. https://doi.org/10.1111/j.1600-079x.2007.00464.x
Cerella C, Diederich M, Ghibelli L. The Dual Role of Calcium as Messenger and Stressor in Cell Damage, Death, and Survival. International Journal of Cell Biology 2010;2010:1-14. https://doi.org/10.1155/2010/546163
Shindyapina A, Mkrtchyan G, Gneteeva T, Buiucli S, Tancowny B, Kulka M, Aliper A, Zhavoronkov A. Mineralization of the Connective Tissue: A Complex Molecular Process Leading to Age-Related Loss of Function. Rejuvenation Research 2014;17(2):116-133. https://doi.org/10.1089/rej.2013.1475
Tan D, Xu B, Zhou X, Reiter R. Pineal Calcification, Melatonin Production, Aging, Associated Health Consequences and Rejuvenation of the Pineal Gland. Molecules 2018;23(2):301. https://doi.org/10.3390/molecules23020301
Mahlberg R, Walther S, Kalus P, Bohner G, Haedel S, Reischies F, Kühl K, Hellweg R, Kunz D. Pineal calcification in Alzheimer's disease: An in vivo study using computed tomography. Neurobiology of Aging 2008;29(2):203-209. https://doi.org/10.1016/j.neurobiolaging.2006.10.003
Sintov A, Yarmolinsky L, Dahan A, Ben-Shabat S. Pharmacological effects of vitamin D and its analogs: recent developments. Drug Discovery Today 2014;19(11):1769-1774. https://doi.org/10.1016/j.drudis.2014.06.008
Maier GS, Horas K, Kurth AA, Lazovic D. Prevalence of Vitamin D Deficiency in Patients with Bone Metastases and Multiple Myeloma. Anticancer Research. 2015;35(11):6281-6285.
Horas K, van Herck U, Maier G, Maus U, Harrasser N, Jakob F, Weissenberger M, Arnholdt J, Holzapfel B, Rudert M. Does vitamin D deficiency predict tumour malignancy in patients with bone tumours? Data from a multi-center cohort analysis. Journal of Bone Oncology 2020;25:100329. https://doi.org/10.1016/j.jbo.2020.100329
Lockley S. Journal of Pineal Research guideline for authors: Measuring melatonin in humans. Journal of Pineal Research 2020;69(2):e12664. https://doi.org/10.1111/jpi.12664
Benloucif S, Burgess H, Klerman E, Lewy A, Middleton B, Murphy P, Parry B, Revell V. Measuring Melatonin in Humans. Journal of Clinical Sleep Medicine 2008;4(1):66-69. https://doi.org/10.5664/jcsm.27083
Mahlberg R, Kienast T, Hädel S, Heidenreich J, Schmitz S, Kunz D. Degree of pineal calcification (DOC) is associated with polysomnographic sleep measures in primary insomnia patients. Sleep Medicine 2009;10(4):439-445. https://doi.org/10.1016/j.sleep.2008.05.003
Wang Y, Han D, Zhou T, Zhang J, Liu C, Cao F, Dong N. Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR‐204‐5p/DPP4 signaling in valvular interstitial cells. Journal of Pineal Research 2020;69(2):. https://doi.org/10.1111/jpi.12666
Xu F, Zhong J, Lin X, Shan S, Guo B, Zheng M, Wang Y, Li F, Cui R, Wu F, Zhou E, Liao X, Liu Y, Yuan L. Melatonin alleviates vascular calcification and ageing through exosomal miR‐204/miR‐211 cluster in a paracrine manner. Journal of Pineal Research 2020;68(3):e12631. https://doi.org/10.1111/jpi.12631
Li Y, Li S, Zhou Y, Meng X, Zhang J, Xu D, Li H. Melatonin for the prevention and treatment of cancer. Oncotarget 2017;8(24):39896-39921. https://doi.org/10.18632/oncotarget.16379
Toma C, Svoboda M, Arrich F, Ekmekcioglu C, Assadian O, Thalhammer T. Expression of the melatonin receptor (MT) 1 in benign and malignant human bone tumors. Journal of Pineal Research 2007;43(2):206-213. https://doi.org/10.1111/j.1600-079x.2007.00464.x
Cheng Y, Cai L, Jiang P, Wang J, Gao C, Feng H, Wang C, Pan H, Yang Y. SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells. European Journal of Pharmacology 2013;715(1-3):219-229. https://doi.org/10.1016/j.ejphar.2013.05.017
Downloads
Published
Issue
Section
License
Copyright (c) 2021 French-Ukrainian Journal of Chemistry
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
