Investigation of aspects of the interaction of the indicators of lipid exchange, trombocitarian block of hemostasis, total body reactivity and their influence on the psychosomatic harmonization of the man in chronic inflammatory processes
Keywords:reproductive health, chronic inflammatory processes, lipid metabolism, platelet level of hemostasis, reactivity, resistance, psychosomatic harmonization
For the first time on the basis of clinical and laboratory researches were revealed the correlation of indicators of lipid metabolism, platelet level of hemostasis and general reactivity in patients with chronic inflammatory processes of the genital system. The new pathogenetic aspects of the course of inflammatory diseases have been established. It has been shown that chronic inflammatory process is accompanied by disorders of lipid metabolism. The degree of severity of these changes depends on the severity of the inflammatory process, the reduction of phagocytic activity of polymorphonuclear leukocytes and the activation of macrophage and specific cellular mechanisms, accompanied by auto-intoxication. It is established that the frequency of atherogenic dyslipoproteinemias, as well as the intensity of lipid peroxidation increases in accordance with the increase age of the examined patients. Most atherogenic dyslipoproteinemias are found in patients with viral and chlamydial infections. The summarized data of the correlation analysis allow us to establish that the growth of atherogenic properties of blood plasma of patients with chronic inflammatory processes of the reproductive system occurs in accordance with the increase of adhesive-aggregation properties of platelets and damage of the vascular endothelium. These shifts occur in parallel with the predominance of the monocyte-macrophage linkage of phagocytosis against the background of reduced activity of neutrophils and cellular mechanisms of development of immunopathological reactions.
Feingold K, Grunfeld C. Lipids: a key player in the battle between the host and microorganisms. Journal of Lipid Research 2012;53(12):2487-2489. https://doi.org/10.1194/jlr.e033407
NEUBAUER R. Free radicals and antioxidants. The Lancet 1994;344(8934):1440-1442. https://doi.org/10.1016/s0140-6736(94)90612-2
Pendergraft W, Rudolph E, Falk R, Jahn J, Grimmler M, Hengst L, Jennette J, Preston G, . Proteinase 3 sidesteps caspases and cleaves p21Waf1/Cip1/Sdi1 to induce endothelial cell apoptosis. Kidney International 2004;65(1):75-84. https://doi.org/10.1111/j.1523-1755.2004.00364.x
Feingold KR, Grunfeld C. Introduction to Lipids and Lipoproteins. In: Feingold KR, Anawalt B, Boyce A, et al., editors. South Dartmouth (MA): MDText.com, Inc.; 2000.
Shibata T, Shimozu Y, Wakita C, Shibata N, Kobayashi M, Machida S, Kato R, Itabe H, Zhu X, Sayre L, Uchida K. Lipid Peroxidation Modification of Protein GeneratesNϵ-(4-Oxononanoyl)lysine as a Pro-inflammatory Ligand. Journal of Biological Chemistry 2011;286(22):19943-19957. https://doi.org/10.1074/jbc.m110.187047
Ishino K, Wakita C, Shibata T, Toyokuni S, Machida S, Matsuda S, Matsuda T, Uchida K. Lipid Peroxidation Generates Body Odor Componenttrans-2-Nonenal Covalently Bound to Proteinin Vivo. Journal of Biological Chemistry 2010;285(20):15302-15313. https://doi.org/10.1074/jbc.m109.068023
Weismann D, Binder C. The innate immune response to products of phospholipid peroxidation. Biochimica et Biophysica Acta (BBA) - Biomembranes 2012;1818(10):2465-2475. https://doi.org/10.1016/j.bbamem.2012.01.018
LENTING P, CASARI C, CHRISTOPHE O, DENIS C. von Willebrand factor: the old, the new and the unknown. Journal of Thrombosis and Haemostasis 2012;10(12):2428-2437. https://doi.org/10.1111/jth.12008
VISCHER U. von Willebrand factor, endothelial dysfunction, and cardiovascular disease. Journal of Thrombosis and Haemostasis 2006;4(6):1186-1193. https://doi.org/10.1111/j.1538-7836.2006.01949.x
van Mourik J, Boertjes R, Huisveld I, Fijnvandraat K, Pajkrt D, van Genderen P, Fijnheer R. von Willebrand Factor Propeptide in Vascular Disorders: A Tool to Distinguish Between Acute and Chronic Endothelial Cell Perturbation. Blood 1999;94(1):179-185. https://doi.org/10.1182/blood.v188.8.131.523k18_179_185
Brott D, Katein A, Thomas H, Lawton M, Montgomery R, Richardson R, Louden C. Evaluation of von Willebrand Factor and von Willebrand Factor Propeptide in Models of Vascular Endothelial Cell Activation, Perturbation, and/or Injury. Toxicologic Pathology 2014;42(4):672-683. https://doi.org/10.1177/0192623313518664
Ambunin VG, Zakharin AK. Conjugation of changes in catecholamines, thiol compounds and lipid peroxidation in bronchial asthma 2011:63-66.
Savchenko RP, Gordyushina IV. Effect of oxidative stress on platelet activation in patients with renal pathology. 2004:48-51.
Suvorov AP. Correction of violations of antioxidant protection in chronic prostatitis by millimeter-wave electromagnetic radiation. 2001:39-41.
Kondakova AP. Intensity of the processes of lymphocyte membrane lipid peroxidation and oxidative modification of plasma proteins in patients with urogenital chlamydiosis. 2014:24-28.
Moore K, Tabas I. Macrophages in the Pathogenesis of Atherosclerosis. Cell 2011;145(3):341-355. https://doi.org/10.1016/j.cell.2011.04.005
Visir V, Makurina G. State of free-radical processes and antioxidant defence of patients with psoriasis and concomitant essential hypertension. Zaporozhye Medical Journal 2016;0(4):21-8. https://doi.org/10.14739/2310-1210.2016.4.79730
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