6-Oxyindan-1-ones with dipeptide chains

Serhiy Shilin, Olga Shablykina, Igor Levkov, Oleksandra Bugera, Zoia Voitenko

Abstract

Through N-acylation of a- or b-amino acid units by 2-(3-oxo-2,3-dihydro-1H-inden-5-yloxy)acetic acid using the method of N-hydroxysuccinimide esters new dipeptide indan-1-one derivatives were obtained. In general, the direct interaction of the acetic carboxyl group of the substrate with the amino group of the a- or b-dipeptide is a more productive strategy than the sequential peptidic condensation of the two amino acids.

Keywords

6-hydroxyindan-1-one; dipeptide derivatives; oxyacetic linker; activated ester method; N-hydroxysuccinimide

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DOI

https://doi.org/10.17721/fujcV7I2P111-119

References

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