6-Oxyindan-1-ones with dipeptide chains


  • Serhiy Shilin
  • Olga Shablykina
  • Igor Levkov
  • Oleksandra Bugera
  • Zoia Voitenko




6-hydroxyindan-1-one, dipeptide derivatives, oxyacetic linker, activated ester method, N-hydroxysuccinimide


Through N-acylation of a- or b-amino acid units by 2-(3-oxo-2,3-dihydro-1H-inden-5-yloxy)acetic acid using the method of N-hydroxysuccinimide esters new dipeptide indan-1-one derivatives were obtained. In general, the direct interaction of the acetic carboxyl group of the substrate with the amino group of the a- or b-dipeptide is a more productive strategy than the sequential peptidic condensation of the two amino acids.


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