Ring closing metathesis strategies to isoxazole containing thiadiazepines

Olexandr Pavluik, Yuriy Bezugly, Volodimir Kashkovsky

Abstract


Cyclic sulfamides are attractive molecules with potential application in medical chemistry. It is known that thiadiazepine-containing derivatives demonstrate promising value in the development of protease inhibitors such as HIV protease, serine protease and metaloprotease. We demonstrate here a comfortable synthetic sequence to symmetric thiadiazepines containing isoxazole substitutents. The structure of the obtained substances was confirmed by 1H, 13C NMR spectroscopy.


Keywords


sulfamides; isoxazole; thiadiazepine; diallyl derivatives; ring closing metathesis

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References


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DOI: https://doi.org/10.17721/fujcV7I1P104-112

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