Ring closing metathesis strategies to isoxazole containing thiadiazepines

Olexandr Pavluik, Yuriy Bezugly, Volodimir Kashkovsky


Cyclic sulfamides are attractive molecules with potential application in medical chemistry. It is known that thiadiazepine-containing derivatives demonstrate promising value in the development of protease inhibitors such as HIV protease, serine protease and metaloprotease. We demonstrate here a comfortable synthetic sequence to symmetric thiadiazepines containing isoxazole substitutents. The structure of the obtained substances was confirmed by 1H, 13C NMR spectroscopy.


sulfamides; isoxazole; thiadiazepine; diallyl derivatives; ring closing metathesis

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