6-Oxyindan-1-ones with amino acid fragments

Serhiy Shilin, Illya Lenko, Olga Shablykina, Volodymyr Khilya

Abstract


New indan-1-one derivatives (8 examples) with amino acid fragments were synthesized through the N-acylation of the amino acids by 2-(3-oxo-2,3-dihydro-1H-inden-5-yloxy)acetic acid using the method of activated N-hydroxysuccinimide esters. To obtain corresponding methyl esters (2 examples) two ways were possible: the N-acylation of the amino acid methyl esters by 2-(3-oxo-2,3-dihydro-1-inden-5-yloxy)acetic acid through the activated imidazole derivatives or methylation of the carboxylic function of preformed N-{[(1-oxoindan-6-yl)oxy]acetyl}amino acids.


Keywords


6-hydroxyindan-1-one; activated ester method; N-hydroxysuccinimide; amino acid derivatives

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DOI: https://doi.org/10.17721/fujcV6I2P18-26

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