Study of Calixarene Complexation with Biologically Active

Olga Kalchenko; Sergiy Cherenok; Sergiy Suikov; Vitaly Kalchenko

doi:10.17721/fujcV5I2P49-55

Authors

Olga Kalchenko Institute of Organic Chemistry National Aademy of Sciences of Ukraine
Sergiy Cherenok Institute of Organic Chemistry National Academy of Sciences of Ukraine
Sergiy Suikov Institute of Organic Chemistry National Academy of Sciences of Ukraine
Vitaly Kalchenko Institute of Organic Chemistry National Academy of Sciences of Ukraine

DOI:

https://doi.org/10.17721/fujcV5I2P49-55

Keywords:

calix[4]arenes, calix[4]resorcinarenes, reversible-phase high performance liquid chromatography, aromatic carboxylc acids, pyridine carboxylic acids, diterpenoid acids, Host-Guest complexes, supramolecular interactions

Abstract

Host-Guest complexation of octakis(diphenoxyphosphoryloxy)tetramethylcalix[4]resorcinarene CRA and 5,17-bis-(N-tolyliminomethyl)-25,27-dipropoxycalix[4]arene CA with bio relevant aromatic, pyridine and diterpenoid carboxylic acids in water-organic solution had been studied by the RP HPLC and molecular modelling methods. The stability constants K_A(387-1914 М^-1) of the supramolecular complexes had been determined. It was shown the Host-Guest interactions are depended on structure of the Host molecules and log P values of the Guests. The complexation is determined by the hydrogen bonds of the COOH group of the carboxylic acids with P=O oxygen atom of diphenoxyphosphoryl group of the calixresorcinarene CRA, and oxygen or nitrogen atoms located on the lower or the upper rim of the calixarene CA.

Author Biographies

Olga Kalchenko, Institute of Organic Chemistry National Aademy of Sciences of Ukraine

Physical-chemical investigations Department

Sergiy Cherenok, Institute of Organic Chemistry National Academy of Sciences of Ukraine

Phosphoranes Department

Sergiy Suikov, Institute of Organic Chemistry National Academy of Sciences of Ukraine

Physical-Chemical Department

Vitaly Kalchenko, Institute of Organic Chemistry National Academy of Sciences of Ukraine

Director of the Institute of Organic Chemistry National Academy of Sciences of Ukraine

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